Antihypoxic Potentiation of Standard Therapy for Experimental Colorectal Liver Metastasis through Myo-Inositol Trispyrophosphate.
Fiche publication
Date publication
décembre 2016
Journal
Clinical cancer research : an official journal of the American Association for Cancer Research
Auteurs
Membres identifiés du Cancéropôle Est :
Pr LEHN Jean-Marie
Tous les auteurs :
Limani P, Linecker M, Kachaylo E, Tschuor C, Kron P, Schlegel A, Ungethuem U, Jang JH, Georgiopoulou S, Nicolau C, Lehn JM, Graf R, Humar B, Clavien PA
Lien Pubmed
Résumé
Tumor hypoxia activates hypoxia-inducible factors (Hifs), which induce a range of malignant changes including vascular abnormalities. Here, we determine whether inhibition of the hypoxic tumor response through myo-inositol trispyrophosphate (ITPP), a compound with antihypoxic properties, is able to cause prolonged vascular normalization that can be exploited to improve standard-of-care treatment.
Référence
Clin. Cancer Res.. 2016 Dec;22(23):5887-5897