Strontium-Substituted Bioceramics Particles: A New Way to Modulate MCP-1 and Gro-α Production by Human Primary Osteoblastic Cells.
Fiche publication
Date publication
décembre 2016
Journal
Materials (Basel, Switzerland)
Auteurs
Membres identifiés du Cancéropôle Est :
Pr GANGLOFF Sophie, Pr LAQUERRIERE Patrice, Dr VELARD Frédéric
Tous les auteurs :
Braux J, Velard F, Guillaume C, Jourdain ML, Gangloff SC, Jallot E, Nedelec JM, Laquerrière P, Laurent-Maquin D
Lien Pubmed
Résumé
To avoid morbidity and limited availability associated with autografts, synthetic calcium phosphate (CaP) ceramics were extensively developed and used as bone filling materials. Controlling their induced-inflammatory response nevertheless remained a major concern. Strontium-containing CaP ceramics were recently demonstrated for impacting cytokines' secretion pattern of human primary monocytes. The present study focuses on the ability of strontium-containing CaP to control the human primary bone cell production of two major inflammatory and pro-osteoclastogenic mediators, namely MCP-1 and Gro-α, in response to ceramics particles.
Référence
Materials (Basel). 2016 Dec;9(12):