Mismatch Repair System Deficiency is associated with response to neoadjuvant chemoradiation in locally advanced rectal cancer.
Fiche publication
Date publication
août 2019
Journal
International journal of radiation oncology, biology, physics
Auteurs
Membres identifiés du Cancéropôle Est :
Dr VERNEREY Dewi
Tous les auteurs :
Meillan N, Vernerey D, Lefèvre JH, Manceau G, Svrcek M, Augustin J, Fléjou JF, Lascols O, Simon JM, Cohen R, Maingon P, Bachet JB, Huguet F
Lien Pubmed
Résumé
Defective mismatch repair system (MMR) has been shown to have a favorable impact on outcome in colorectal cancer patients treated with surgery or immunotherapy, adjuvant chemotherapy being discouraged unless there is nodal involvement. Its impact on radiosensitivity is unknown in rectal cancer patients.
Mots clés
MSI, Neoajduvant, chemoradiation, defective mismatch repair system, neoadjuvant treatment, pathological results, rectal cancer, surgery, survival
Référence
Int. J. Radiat. Oncol. Biol. Phys.. 2019 Aug 9;: