Light-sensitive dextran-covered PNBA nanoparticles to continuously or discontinuously improve the drug release.
Fiche publication
Date publication
juillet 2019
Journal
Colloids and surfaces. B, Biointerfaces
Auteurs
Membres identifiés du Cancéropôle Est :
Dr VANDERESSE Régis
Tous les auteurs :
Soliman SMA, El Founi M, Vanderesse R, Acherar S, Ferji K, Babin J, Six JL
Lien Pubmed
Résumé
In this work, photo-sensitive core/shell nanoparticles (NPs) based on biocompatible dextran-g-poly(o-nitrobenzyl acrylate) copolymers (Dex-g-PNBA), containing dextran as hydrophilic backbone and PNBA as photosensitive grafts, were formulated using two processes. In the first process (nanoprecipitation), NPs were prepared using preformed Dex-g-PNBA copolymers. Using the second process (emulsion/organic solvent evaporation), "clicked" or "unclicked" NPs were obtained carrying out (or not) an interfacial in situ click chemistry, respectively. Two model molecules, Nile Red (NR) and Doxorubicin (DOX), were encapsulated and their controlled release from NPs was investigated under UV irradiations to demonstrate the high potential of such photosensitive NPs in biomedicine applications as drug delivery nanocarriers. According to such irradiations, improved release was easily observed. Release kinetics depended on the formulation process and the NPs core chemistry, but not on the occurrence of the interfacial in situ click chemistry. More interesting, a stepped release of such model molecules may easily be obtained.
Mots clés
Anticancer, Drug delivery system, Glycopolymer, Light-responsive, Light-triggered, Photo-responsive polymer, Polysaccharide
Référence
Colloids Surf B Biointerfaces. 2019 Jul 24;182:110393