Staphylococcus aureus RNAIII and Its Regulon Link Quorum Sensing, Stress Responses, Metabolic Adaptation, and Regulation of Virulence Gene Expression.
Fiche publication
Date publication
septembre 2016
Journal
Annual review of microbiology
Auteurs
Membres identifiés du Cancéropôle Est :
Dr ROMBY Pascale
Tous les auteurs :
Bronesky D, Wu Z, Marzi S, Walter P, Geissmann T, Moreau K, Vandenesch F, Caldelari I, Romby P
Lien Pubmed
Résumé
Staphylococcus aureus RNAIII is one of the main intracellular effectors of the quorum-sensing system. It is a multifunctional RNA that encodes a small peptide, and its noncoding parts act as antisense RNAs to regulate the translation and/or the stability of mRNAs encoding transcriptional regulators, major virulence factors, and cell wall metabolism enzymes. In this review, we explain how regulatory proteins and RNAIII are embedded in complex regulatory circuits to express virulence factors in a dynamic and timely manner in response to stress and environmental and metabolic changes.
Mots clés
Animals, Bacterial Proteins, Gene Expression Regulation, Bacterial, Humans, Quorum Sensing, RNA, Bacterial, genetics, Regulon, Staphylococcal Infections, microbiology, Staphylococcus aureus, enzymology, Virulence, Virulence Factors, genetics
Référence
Annu. Rev. Microbiol.. 2016 09 8;70:299-316