The effect of neuropeptide FF in the amygdala kindling model.
Fiche publication
Date publication
septembre 2016
Journal
Acta neurologica Scandinavica
Auteurs
Membres identifiés du Cancéropôle Est :
Dr SIMONIN Frédéric
Tous les auteurs :
Buffel I, Meurs A, Portelli J, Raedt R, De Herdt V, Poppe L, De Meulenaere V, Wadman W, Bihel F, Schmitt M, Vonck K, Bourguignon JJ, Simonin F, Smolders I, Boon P
Lien Pubmed
Résumé
Neuropeptide FF (NPFF) and its receptors (NPFF1 R and NPFF2 R) are differentially distributed throughout the central nervous system. NPFF reduces cortical excitability in rats when administered intracerebroventricularly (i.c.v.), and both NPFF and NPFF1 R antagonists attenuate pilocarpine-induced limbic seizures. In this study, our aim was to determine whether NPFF exerts anticonvulsant or anti-epileptogenic effects in the rat amygdala kindling model for temporal lobe seizures.
Mots clés
Amygdala, drug effects, Animals, Anticonvulsants, administration & dosage, Disease Models, Animal, Epilepsy, Temporal Lobe, drug therapy, Kindling, Neurologic, drug effects, Male, Oligopeptides, administration & dosage, Rats, Rats, Wistar, Seizures, drug therapy
Référence
Acta Neurol. Scand.. 2016 Sep;134(3):181-8