Supported Catalytically-Active Supramolecular Hydrogels for Continuous Flow Chemistry.
Fiche publication
Date publication
octobre 2019
Journal
Angewandte Chemie (International ed. in English)
Auteurs
Membres identifiés du Cancéropôle Est :
Pr SCHAAF Pierre, Dr SCHMUTZ Marc
Tous les auteurs :
Rodon Fores J, Criado-Gonzalez M, Chaumont A, Carvalho A, Blanck C, Schmutz M, Serra CA, Boulmedais F, Schaaf P, Jierry L
Lien Pubmed
Résumé
Inspired from biology, one current goal in supramolecular chemistry is to control the emergence of new functionalities arising from self-assembly of molecules. In particular, some peptides can self-assemble and lead to exceptional catalytically-active fibrous networks able to underpin hydrogels. Unfortunately, the mechanical fragility of these materials is incompatible with process developments relaying this exciting field to academic curiosity. Here, we show that this drawback can be circumvented using enzyme-assisted self-assembly of peptides initiated at the walls of a supporting porous material. We apply this strategy to grow an esterase-like catalytically-active supramolecular hydrogel (CASH) in an open-cell polymer foam, filling the whole interior space of it. Our so-supported-CASH is highly efficient toward inactivated esters and shows kinetic resolution of racemates. This hybrid material is robust enough to be used in continuous flow reactors, reusable and stable over months.
Mots clés
Enzyme-assisted self-assembly Gels Organocatalysis Supported catalysis kinetic resolution
Référence
Angew. Chem. Int. Ed. Engl.. 2019 Oct 1;: