Sepiolite as a New Nanocarrier for DNA Transfer into Mammalian Cells: Proof of Concept, Issues and Perspectives.
Fiche publication
Date publication
juillet 2018
Journal
Chemical Record
Auteurs
Membres identifiés du Cancéropôle Est :
Dr PIETREMENT Olivier
Tous les auteurs :
Piétrement O, Castro-Smirnov FA, Le Cam E, Aranda P, Ruiz-Hitzky E, Lopez BS.
Lien Pubmed
Résumé
Sepiolite is a nanofibrous natural silicate that can be used as a nanocarrier for DNA transfer thanks to its strong interaction with DNA molecules and its ability to be naturally internalized into mammalian cells through both non-endocytic and endocytic pathways. Sepiolite, due to its ability to bind various biomolecules, could be a good candidate for use as a nanocarrier for the simultaneous vectorization of diverse biological molecules. In this paper, we review our recent work, issued from a starting collaboration with Prof. Ruiz-Hitzky, that includes diverse aspects on the characterization and main features of sepiolite/DNA nanohybrids, and we present an outlook for the further development of sepiolite for DNA transfer.
Mots clés
Clays; DNA; Mammalian Cell transfection; Sepiolite
Référence
Chem Rec.. 2018 07;18(7-8):849-857