Herpes simplex virus type 1 hepatitis due to primary infection in a pancreas-kidney transplant recipient.
Fiche publication
Date publication
juillet 2016
Journal
Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology
Auteurs
Membres identifiés du Cancéropôle Est :
Dr JEULIN Hélène
Tous les auteurs :
Feugeas J, Mory S, Jeulin H, Velay A, Pertek JP, Ladriere M, Losser MR
Lien Pubmed
Résumé
Herpes simplex Virus (HSV) hepatitis is a rare complication of HSV-1 primary infection, with a delayed diagnosis, affecting mainly immunocompromised patients. We describe a case of HSV-1 hepatitis after primary infection occurring in the postoperative days after a pancreas-kidney transplantation. The patient presented with an unusual evolution of a persistent severe hepatitis associated with a persistent viremia (Quantitative Polymerase Chain Reaction) despite an adequate intravenous (iv) antiviral treatment. Abdominal computed tomography scan showed a miliary hepatitis. The diagnosis of HSV-1 hepatitis was confirmed by immuno-chemistry on liver biopsy. The donor was negative for anti-HSV antibodies, excluding contamination by the graft. This case report emphasizes a rather seldom risk of care-associated viral infections, predominantly in immunocompromised patients.
Référence
J. Clin. Virol.. 2016 Jul;80:57-9