Standardization of a well-controlled in vivo mouse model of thrombus formation induced by mechanical injury.
Fiche publication
Date publication
mai 2016
Journal
Thrombosis research
Auteurs
Membres identifiés du Cancéropôle Est :
Dr GACHET Christian
Tous les auteurs :
Tang C, Wang Y, Lei D, Huang L, Wang G, Chi Q, Zheng Y, Gachet C, Mangin PH, Zhu L
Lien Pubmed
Résumé
Vascular plug formation by mechanical injury that exposes abundant extracellular matrix is an ideal model to mimic thrombus formation. The objective of this study was to standardize our previously established in vivo mouse model of thrombus formation induced by mechanical injury.
Mots clés
Animals, Aorta, drug effects, Disease Models, Animal, Endothelium, Vascular, drug effects, Hirudin Therapy, methods, Male, Mice, Mice, Inbred C57BL, Peptides, therapeutic use, Platelet Aggregation Inhibitors, therapeutic use, Platelet Glycoprotein GPIIb-IIIa Complex, antagonists & inhibitors, Stress, Mechanical, Thrombosis, drug therapy, Ticlopidine, analogs & derivatives
Référence
Thromb. Res.. 2016 May;141:49-57