Antibacterial and cytotoxic triterpenoids from the roots of Combretum racemosum.
Fiche publication
Date publication
avril 2016
Journal
Fitoterapia
Auteurs
Membres identifiés du Cancéropôle Est :
Pr GANGLOFF Sophie, Pr MORJANI Hamid
Tous les auteurs :
Gossan DP, Alabdul Magid A, Yao-Kouassi PA, Josse J, Gangloff SC, Morjani H, Voutquenne-Nazabadioko L
Lien Pubmed
Résumé
A new pentacyclic triterpenoid glucoside, together with fourteen known compounds, was isolated from the roots of Combretum racemosum. Combretaceae). The structure of the new compound was established as 28-O-β-d-glucopyranosyl-2α,3β,21β,23-tetrahydroxyolean-18-en-28-oate (1) on the basis of detailed spectroscopic data including MS, 1D, and 2D NMR. The inhibitory activity of compounds 1-15 against promyelocytic leukemia HL-60 and human erythromyeloblastoid leukemia K562 cell lines was evaluated. Compounds 11 (3-O-β-acetyl-ursolic acid), 14 (betulinic acid), and 15 (quadranoside II) exhibited significant cytotoxicity, with IC50 values of 13 to 50 μM. Among the isolated triterpenes, compounds 1, 3 (arjungenin), 5 (terminolic acid), and 11 exhibited moderate antibacterial activity against Staphylococcus aureus, Escherichia coli and Enterococcus faecalis (MICs within a range of 64 and 256 μg/mL).
Mots clés
Anti-Bacterial Agents, chemistry, Combretum, chemistry, Cote d'Ivoire, Enterococcus faecalis, drug effects, Escherichia coli, drug effects, Glucosides, chemistry, HL-60 Cells, Humans, Inhibitory Concentration 50, K562 Cells, Magnetic Resonance Spectroscopy, Microbial Sensitivity Tests, Molecular Structure, Plant Roots, chemistry, Staphylococcus aureus, drug effects, Triterpenes, chemistry
Référence
Fitoterapia. 2016 Apr;110:89-95