Another hijack! Some enteroviruses co-opt the c10orf76/PI4KB complex for their own good.
Fiche publication
Date publication
janvier 2020
Journal
EMBO reports
Auteurs
Membres identifiés du Cancéropôle Est :
Dr ALPY Fabien
Tous les auteurs :
Voilquin L, Di Mattia T, Alpy F
Lien Pubmed
Résumé
Enteroviruses, members of the Picornaviridae family, are non-enveloped and single-stranded RNA viruses responsible for several human diseases. During infection, these viruses build membrane-bound organelles, called replication organelles (ROs), where new virions are assembled. ROs are highly enriched in phosphatidylinositol 4-phosphate (PI4P) produced by the host lipid kinase PI4KB. In this issue of EMBO Reports, McPhail et al [1] characterize a complex, formed by PI4KB and the c10orf76 protein, which is involved in PI4P production. They show that this machinery is hijacked by specific enteroviruses such as coxsackievirus A10 for their replication.
Référence
EMBO Rep.. 2020 Jan 9;:e49876