[Potentiation strategies].
Fiche publication
Date publication
mars 2016
Journal
Presse medicale (Paris, France : 1983)
Auteurs
Membres identifiés du Cancéropôle Est :
Pr HAFFEN Emmanuel
Tous les auteurs :
Doumy O, Bennabi D, El-Hage W, Allaïli N, Bation R, Bellivier F, Holtzmann J, Bubrovszky M, Camus V, Charpeaud T, Courvoisier P, d'Amato T, Garnier M, Haesebaert F, Bougerol T, Lançon C, Moliere F, Nieto I, Richieri R, Saba G, Courtet P, Vaiva G, Leboyer M, Llorca PM, Aouizerate B, Haffen E
Lien Pubmed
Résumé
Lithium is among the most classically recommended add-on therapeutic strategy for the management of depressive patients showing unsuccessful response to standard antidepressant medications. The effectiveness of the add-on strategy with lithium requires achieving plasma levels above 0.5 mEq/L. Mood-stabilizing antiepileptic drugs such as carbamazepine, valproate derivatives or lamotrigine have not demonstrated conclusive therapeutic effects for the management of depressive patients showing unsuccessful response to standard antidepressant medications. Thyroid hormones are considered among the currently recommended add-on therapeutic strategy for the management of depressive patients showing unsuccessful response to standard antidepressant medications. The effectiveness of the add-on strategy with thyroid hormones requires achieving plasma concentration of TSH close to the lower limits at the normal range (0.4 μUI/L) or even below it. Second-generation antipsychotics such as aripiprazole or quetiapine have consistently demonstrated significant therapeutic effects for the management of depressive patients showing unsuccessful response to standard antidepressant medications. Second-generation antipsychotics however require the careful monitoring of both cardiovascular and metabolic adverse effects.
Mots clés
Anticonvulsants, pharmacokinetics, Antidepressive Agents, classification, Antipsychotic Agents, adverse effects, Bipolar Disorder, drug therapy, Depressive Disorder, drug therapy, Double-Blind Method, Drug Resistance, Drug Synergism, Drug Therapy, Combination, Humans, Lithium Carbonate, pharmacokinetics, Meta-Analysis as Topic, Practice Guidelines as Topic, Randomized Controlled Trials as Topic, Thyroid Hormones, pharmacokinetics, Thyrotropin, blood, Treatment Outcome
Référence
Presse Med. 2016 Mar;45(3):338-49