An oxidatively damaged G-quadruplex/hemin DNAzyme.
Fiche publication
Date publication
janvier 2020
Journal
Chemical communications (Cambridge, England)
Auteurs
Membres identifiés du Cancéropôle Est :
Dr MONCHAUD David
Tous les auteurs :
Wang J, Cheng M, Chen J, Ju H, Monchaud D, Mergny JL, Zhou J
Lien Pubmed
Résumé
Oxidative damage of guanine to 8-oxoguanine triggers a partial and variable loss of G-quadruplex/hemin DNAzyme activity and provides clues to the mechanistic origins of DNAzyme deactivation, which originates from an interplay between decreased G-quadruplex stability, lower hemin affinity and a modification of the nature of hemin binding sites.
Référence
Chem. Commun. (Camb.). 2020 Jan 17;: