Modulation of Cell Identity by Modification of Nuclear Pore Complexes.
Fiche publication
Date publication
janvier 2019
Journal
Frontiers in genetics
Auteurs
Membres identifiés du Cancéropôle Est :
Dr MENDOZA Manuel
Tous les auteurs :
Gomar-Alba M, Mendoza M
Lien Pubmed
Résumé
Nuclear pore complexes (NPCs) are protein assemblies that form channels across the nuclear envelope to mediate communication between the nucleus and the cytoplasm. Additionally, NPCs interact with chromatin and influence the position and expression of multiple genes. Interestingly, the composition of NPCs can vary in different cell-types, tissues, and developmental states. Here, we review recent findings suggesting that modifications of NPC composition, including post-translational modifications, play an instructive role in cell fate establishment. In particular, we focus on the role of cell-specific NPC deacetylation in asymmetrically dividing budding yeast, which modulates transport-dependent and transport-independent NPC functions to determine the time of commitment to a new division cycle in daughter cells. By modulating protein localization and gene expression, NPCs are therefore emerging as central regulators of cell identity.
Mots clés
Hos3, budding yeast, cell differentiation, deacetylase, nuclear pore complex
Référence
Front Genet. 2019 ;10:1301