Human skin penetration of hyaluronic acid of different molecular weights as probed by Raman spectroscopy.
Fiche publication
Date publication
février 2016
Journal
Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI)
Auteurs
Membres identifiés du Cancéropôle Est :
Dr GOBINET Cyril, Pr PIOT Olivier
Tous les auteurs :
Essendoubi M, Gobinet C, Reynaud R, Angiboust JF, Manfait M, Piot O
Lien Pubmed
Résumé
Topical delivery of molecules into the human skin is one of the main issues in dermatology and cosmetology. Several techniques were developed to study molecules penetration into the human skin. Although widely accepted, the conventional methods such as Franz diffusion cells are unable to provide the accurate localization of actives in the skin layers. A different approach based on Raman spectroscopy has been proposed to follow-up the permeation of actives. It presents a high molecular specificity to distinguish exogenous molecules from skin constituents.
Mots clés
Administration, Cutaneous, Adult, Female, Humans, Hyaluronic Acid, administration & dosage, In Vitro Techniques, Molecular Weight, Skin, chemistry, Skin Absorption, physiology, Spectrum Analysis, Raman, methods, Structure-Activity Relationship
Référence
Skin Res Technol. 2016 Feb;22(1):55-62