How Does Circadian Rhythm Impact Salt Sensitivity of Blood Pressure in Mice? A Study in Two Close C57Bl/6 Substrains.
Fiche publication
Date publication
janvier 2016
Journal
PloS one
Auteurs
Membres identifiés du Cancéropôle Est :
Dr HERAULT Yann, Dr SORG Tania
Tous les auteurs :
Combe R, Mudgett J, El Fertak L, Champy MF, Ayme-Dietrich E, Petit-Demoulière B, Sorg T, Herault Y, Madwed JB, Monassier L
Lien Pubmed
Résumé
Mouse transgenesis has provided the unique opportunity to investigate mechanisms underlying sodium kidney reabsorption as well as end organ damage. However, understanding mouse background and the experimental conditions effects on phenotypic readouts of engineered mouse lines such as blood pressure presents a challenge. Despite the ability to generate high sodium and chloride plasma levels during high-salt diet, observed changes in blood pressure are not consistent between wild-type background strains and studies.
Mots clés
Animals, Blood Pressure, drug effects, Blood Pressure Determination, methods, Circadian Rhythm, physiology, Diet, Sodium-Restricted, Heart Rate, drug effects, Hypertension, chemically induced, Male, Mice, Inbred C57BL, genetics, Potassium, blood, Sodium, blood, Sodium Chloride, Dietary, adverse effects, Sodium, Dietary, adverse effects, Telemetry
Référence
PLoS ONE. 2016 ;11(4):e0153472