Glycosyl phosphatidylinositol (GPI)/inositolphosphate glycan (IPG): an intracellular signalling system involved in the control of thyroid cell proliferation.
Fiche publication
Date publication
décembre 1998
Journal
Biochimie
Auteurs
Membres identifiés du Cancéropôle Est :
Pr MARTINY Laurent, Dr EL BTAOURI Hassan
Tous les auteurs :
Petitfrere E, Sartelet H, Vivien D, Varela-Nieto I, Elbtaouri H, Martiny L, Haye B
Lien Pubmed
Résumé
In porcine thyrocytes, TSH alone does not induce cell growth. Recently, it has been demonstrated that acute stimulation by TSH of porcine thyrocytes leads to release an inositolphosphate glycan (IPG) described as a putative second messenger for various growth factors in different cell types. IPG isolated from porcine thyrocytes induces proliferation of fibroblasts EGFR T17 and porcine thyrocytes. In porcine thyrocytes we have confirmed that cell growth requires the presence of both TSH and insulin. This effect is reproduced by 8-bromo cyclic AMP suggesting a mediation by intracellular cyclic AMP. Cooperative effects between 8-bromo cyclic AMP and IPG have also been evidenced and are in favour of a crosstalk between distinct signalling pathways.
Mots clés
3T3 Cells, Animals, Cell Division, Cells, Cultured, Cyclic AMP, metabolism, Glycosylphosphatidylinositols, metabolism, Inositol Phosphates, metabolism, Mice, Polysaccharides, metabolism, Rats, Signal Transduction, Swine, Thyroid Gland, cytology, Thyrotropin, physiology
Référence
Biochimie. 1998 Dec;80(12):1063-7