Sex differences in mineralocorticoid receptor antagonist trials: a pooled analysis of three large clinical trials.
Fiche publication
Date publication
février 2020
Journal
European journal of heart failure
Auteurs
Membres identifiés du Cancéropôle Est :
Pr ROSSIGNOL Patrick
Tous les auteurs :
Rossello X, Ferreira JP, Pocock SJ, McMurray JJV, Solomon SD, Lam CSP, Girerd N, Pitt B, Rossignol P, Zannad F
Lien Pubmed
Résumé
Women with heart failure (HF) are under-represented in individual randomized clinical trials (RCTs). Little is known about sex-specific treatment effects in HF medications. We evaluated sex differences in the response to mineralocorticoid receptor antagonists (MRAs) in major HF MRA trials, including a broad spectrum of left ventricular ejection fraction (LVEF).
Mots clés
Heart failure, Meta-analysis, Mineralocorticoid receptor antagonists, Women
Référence
Eur. J. Heart Fail.. 2020 Feb 19;: