Comparable Senescence Induction in Three-dimensional Human Cartilage Model by Exposure to Therapeutic Doses of X-rays or C-ions.
Fiche publication
Date publication
mai 2016
Journal
International journal of radiation oncology, biology, physics
Auteurs
Membres identifiés du Cancéropôle Est :
Dr GROETZ Jean-Emmanuel
Tous les auteurs :
Hamdi DH, Chevalier F, Groetz JE, Durantel F, Thuret JY, Mann C, Saintigny Y
Lien Pubmed
Résumé
Particle therapy using carbon ions (C-ions) has been successfully used in the treatment of tumors resistant to conventional radiation therapy. However, the potential side effects to healthy cartilage exposed to lower linear energy transfer (LET) ions in the beam track before the tumor have not been evaluated. The aim of the present study was to assess the extent of damage after C-ion irradiation in a 3-dimensional (3D) cartilage model close to human homeostasis.
Mots clés
Bone Neoplasms, radiotherapy, Carbon, Cartilage, cytology, Cell Culture Techniques, Cell Death, Cell Survival, radiation effects, Cells, Cultured, Cellular Senescence, Chondrocytes, radiation effects, Chondrosarcoma, radiotherapy, Heavy Ion Radiotherapy, adverse effects, Humans, Linear Energy Transfer, Radiation Injuries, complications, Relative Biological Effectiveness, X-Rays
Référence
Int. J. Radiat. Oncol. Biol. Phys.. 2016 May 1;95(1):139-146