Effects of Bioactive Marine-Derived Liposomes on Two Human Breast Cancer Cell Lines.
Fiche publication
Date publication
avril 2020
Journal
Marine drugs
Auteurs
Membres identifiés du Cancéropôle Est :
Dr FRANCIUS Grégory, Pr GRANDEMANGE Stéphanie
Tous les auteurs :
Li J, Elkhoury K, Barbieux C, Linder M, Grandemange S, Tamayol A, Francius G, Arab-Tehrany E
Lien Pubmed
Résumé
Breast cancer is the leading cause of death from cancer among women. Higher consumption of dietary marine n-3 long-chain polyunsaturated fatty acids (LC-PUFAs) is associated with a lower risk of breast cancer. Eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) are two n-3 LC-PUFAs found in fish and exert anticancer effects. In this study, natural marine-derived lecithin that is rich in various polyunsaturated fatty acids (PUFAs) was extracted from salmon heads and transformed into nanoliposomes. These nanoliposomes were characterized and cultured with two breast cancer lines (MCF-7 and MDA-MB-231). The nanoliposomes decreased the proliferation and the stiffness of both cancer cell types. These results suggest that marine-derived lecithin possesses anticancer properties, which may have an impact on developing new liposomal delivery strategies for breast cancer treatment.
Mots clés
DHA, EPA, PUFA, breast cancer, liposomes, omega-3
Référence
Mar Drugs. 2020 Apr 13;18(4):