Stem cells: a promising source for vascular regenerative medicine.

Fiche publication


Date publication

décembre 2014

Journal

Stem cells and development

Auteurs

Membres identifiés du Cancéropôle Est :
Pr MENU Patrick, Dr KERDJOUDJ Halima


Tous les auteurs :
Rammal H, Harmouch C, Lataillade JJ, Laurent-Maquin D, Labrude P, Menu P, Kerdjoudj H

Résumé

The rising and diversity of many human vascular diseases pose urgent needs for the development of novel therapeutics. Stem cell therapy represents a challenge in the medicine of the twenty-first century, an area where tissue engineering and regenerative medicine gather to provide promising treatments for a wide variety of diseases. Indeed, with their extensive regeneration potential and functional multilineage differentiation capacity, stem cells are now highlighted as promising cell sources for regenerative medicine. Their multilineage differentiation involves environmental factors such as biochemical, extracellular matrix coating, oxygen tension, and mechanical forces. In this review, we will focus on human stem cell sources and their applications in vascular regeneration. We will also discuss the different strategies used for their differentiation into both mature and functional smooth muscle and endothelial cells.

Mots clés

Animals, Humans, Neovascularization, Physiologic, Regenerative Medicine, methods, Stem Cell Transplantation, methods, Stem Cells, classification

Référence

Stem Cells Dev.. 2014 Dec;23(24):2931-49