Nonlinear feedback drives homeostatic plasticity in HO stress response.
Fiche publication
Date publication
avril 2017
Journal
eLife
Auteurs
Membres identifiés du Cancéropôle Est :
Dr CHARVIN Gilles
Tous les auteurs :
Goulev Y, Morlot S, Matifas A, Huang B, Molin M, Toledano MB, Charvin G
Lien Pubmed
Résumé
Homeostatic systems that rely on genetic regulatory networks are intrinsically limited by the transcriptional response time, which may restrict a cell's ability to adapt to unanticipated environmental challenges. To bypass this limitation, cells have evolved mechanisms whereby exposure to mild stress increases their resistance to subsequent threats. However, the mechanisms responsible for such remain largely unknown. Here, we used live-cell imaging and microfluidics to investigate the adaptive response of budding yeast to temporally controlled HO stress patterns. We demonstrate that acquisition of tolerance is a systems-level property resulting from nonlinearity of HO scavenging by peroxiredoxins and our study reveals that this regulatory scheme induces a striking hormetic effect of extracellular HO stress on replicative longevity. Our study thus provides a novel quantitative framework bridging the molecular architecture of a cellular homeostatic system to the emergence of nonintuitive adaptive properties.
Mots clés
H2O2 homeostasis, S. cerevisiae, acquired stress resistance, adaptation, cell biology, computational biology, hormesis, nonlinear feedback, systems biology
Référence
Elife. 2017 04 18;6: