Long non-coding RNA profiling links subgroup classification of endometrioid endometrial carcinomas with trithorax and polycomb complex aberrations.
Fiche publication
Date publication
novembre 2015
Journal
Oncotarget
Auteurs
Membres identifiés du Cancéropôle Est :
Pr MALOUF Gabriel
Tous les auteurs :
Jiang Y, Malouf GG, Zhang J, Zheng X, Chen Y, Thompson EJ, Weinstein JN, Yuan Y, Spano JP, Broaddus R, Tannir NM, Khayat D, Lu KH, Su X
Lien Pubmed
Résumé
Integrative analysis of endometrioid endometrial carcinoma (EEC) using multiple platforms has distinguished four molecular subgroups. However, the landscape of expressed long non-coding RNAs (lncRNA) and their role in charting EEC subgroups and determining clinical aggressiveness remain largely unknown.
Mots clés
Carcinoma, Endometrioid, genetics, Cluster Analysis, Endometrial Neoplasms, genetics, Enhancer of Zeste Homolog 2 Protein, Estrogen Receptor alpha, genetics, Female, Gene Expression Profiling, methods, Gene Expression Regulation, Neoplastic, Histone-Lysine N-Methyltransferase, genetics, Humans, Kaplan-Meier Estimate, Mutation, Myeloid-Lymphoid Leukemia Protein, genetics, Polycomb Repressive Complex 1, genetics, Polycomb Repressive Complex 2, genetics, Polycomb-Group Proteins, genetics, RNA, Long Noncoding, classification, Receptors, Progesterone, genetics, Signal Transduction, genetics, beta Catenin, genetics
Référence
Oncotarget. 2015 Nov 24;6(37):39865-76