Reduced Neurog3 Gene Dosage Shifts Enteroendocrine Progenitor Towards Goblet Cell Lineage in the Mouse Intestine.
Fiche publication
Date publication
août 2020
Journal
Cellular and molecular gastroenterology and hepatology
Auteurs
Membres identifiés du Cancéropôle Est :
Dr GRADWOHL Gérard
Tous les auteurs :
Li HJ, Ray SK, Kucukural A, Gradwohl G, Leiter AB
Lien Pubmed
Résumé
Transient expression of Neurog3 commits intestinal secretory progenitors to become enteroendocrine-biased progenitors and hence drive enteroendocrine differentiation. Loss of Neurog3 in mouse resulted in the depletion of intestinal enteroendocrine cells (EECs) and an increase in goblet cells. Earlier studies in developing mouse pancreas revealed Neurog3 gene dosage in endocrine and exocrine cell fate allocation. We aim to determine whether Neurog3 gene dosage controls fate choice of enteroendocrine progenitors.
Mots clés
Enteroendocrine progenitors, Neurog3 Gene dosage, goblet cell differentiation
Référence
Cell Mol Gastroenterol Hepatol. 2020 Aug 18;: