Vibrational spectroscopy of liquid biopsies for prostate cancer diagnosis.
Fiche publication
Date publication
janvier 2020
Journal
Therapeutic advances in medical oncology
Auteurs
Membres identifiés du Cancéropôle Est :
Pr SOCKALINGUM Ganesh
Tous les auteurs :
Medipally DKR, Cullen D, Untereiner V, Sockalingum GD, Maguire A, Nguyen TNQ, Bryant J, Noone E, Bradshaw S, Finn M, Dunne M, Shannon AM, Armstrong J, Meade AD, Lyng FM
Lien Pubmed
Résumé
Screening for prostate cancer with prostate specific antigen and digital rectal examination allows early diagnosis of prostate malignancy but has been associated with poor sensitivity and specificity. There is also a considerable risk of over-diagnosis and over-treatment, which highlights the need for better tools for diagnosis of prostate cancer. This study investigates the potential of high throughput Raman and Fourier Transform Infrared (FTIR) spectroscopy of liquid biopsies for rapid and accurate diagnosis of prostate cancer.
Mots clés
FTIR spectroscopy, Raman spectroscopy, liquid biopsy, partial least squares discriminant analysis and classical least squares fitting analysis, principal component analysis, prostate cancer
Référence
Ther Adv Med Oncol. 2020 ;12:1758835920918499