CXCL10 could drive longer duration of mechanical ventilation during COVID-19 ARDS.
Fiche publication
Date publication
novembre 2020
Journal
Critical care (London, England)
Auteurs
Membres identifiés du Cancéropôle Est :
Pr BINQUET Christine, Dr PAIS DE BARROS Jean-Paul, Pr MASSON David, Pr BONNIAUD Philippe, Dr BELTRAMO Guillaume
Tous les auteurs :
Blot M, Jacquier M, Aho Glele LS, Beltramo G, Nguyen M, Bonniaud P, Prin S, Andreu P, Bouhemad B, Bour JB, Binquet C, Piroth L, Pais de Barros JP, Masson D, Quenot JP, Charles PE,
Lien Pubmed
Résumé
COVID-19-related ARDS has unique features when compared with ARDS from other origins, suggesting a distinctive inflammatory pathogenesis. Data regarding the host response within the lung are sparse. The objective is to compare alveolar and systemic inflammation response patterns, mitochondrial alarmin release, and outcomes according to ARDS etiology (i.e., COVID-19 vs. non-COVID-19).
Mots clés
Acute respiratory distress syndrome, Biomarker, Bronchoalveolar lavage, COVID-19, CXCL10, Immune response, Mechanical ventilation, Mitochondrial DNA, SARS-CoV-2
Référence
Crit Care. 2020 11 2;24(1):632