A pilot study of procoagulant platelet extracellular vesicles and P-selectin increase during induction treatment in acute lymphoblastic leukaemia paediatric patients: two new biomarkers of thrombogenic risk?
Fiche publication
Date publication
novembre 2020
Journal
Journal of thrombosis and thrombolysis
Auteurs
Membres identifiés du Cancéropôle Est :
Pr NGUYEN Philippe, Dr AUDONNET Sandra
Tous les auteurs :
Pluchart C, Barbe C, Poitevin G, Audonnet S, Nguyen P
Lien Pubmed
Résumé
In paediatric acute lymphoblastic leukaemia (ALL), focus has shifted towards preventing treatment-related complications, including venous thromboembolism, the cause of significant mortality and morbidity. To better understand thrombogenic mechanisms during induction treatment, we studied the number, origin and procoagulant activity of extracellular vesicles (EVs) and P-selectin level throughout the induction course in 24 paediatric patients. EVs were mainly of platelet origin. We observed a significant increase in EV number, in platelet EV number and P-selectin level throughout the induction course. There was a correlation between higher EV and platelet EV number, P-selectin level, higher platelet count and leucocyte count. We also observed a correlation between higher EV procoagulant activity and higher platelet count and leucocyte count and higher P-selectin level. Older age and T phenotype were associated with a higher EV procoagulant activity. Platelet EV generation may play a role in thrombogenic complications in ALL patients and could serve as a biomarker to identify patients with a high risk of thrombosis. As a marker of platelet activation, P-selectin may be another relevant marker with the advantage of being easier to analyse in clinical practice.
Mots clés
Acute lymphoblastic leukaemia, Extracellular vesicles, Platelets, Venous thromboembolism
Référence
J Thromb Thrombolysis. 2020 Nov 28;: