Investigation of the prognostic value of CD4 T cell subsets expanded from tumor-infiltrating lymphocytes of colorectal cancer liver metastases.
Fiche publication
Date publication
novembre 2020
Journal
Journal for immunotherapy of cancer
Auteurs
Membres identifiés du Cancéropôle Est :
Pr ADOTEVI Olivier, Pr BORG Christophe, Dr GODET Yann, Mme BOUARD Adeline, Dr DESCHAMPS Marina, Pr HEYD Bruno, Dr LOYON Romain, Dr KROEMER Marie
Tous les auteurs :
Kroemer M, Turco C, Spehner L, Viot J, Idirène I, Bouard A, Renaude E, Deschamps M, Godet Y, Adotévi O, Limat S, Heyd B, Jary M, Loyon R, Borg C
Lien Pubmed
Résumé
The positive role of CD8+ tumor-infiltrating lymphocytes (TIL) in patients with colorectal cancer (CRC) has been well described but the prognostic value of CD4 T cell subsets remained to be investigated. In this study, we expanded TIL from surgically resected liver metastases of patients with CRC and characterized the phenotype and the prognostic value of expanded-CD4 T cells.
Mots clés
CD4-positive t-lymphocytes, adaptive immunity, biomarkers, gastrointestinal neoplasms, lymphocytes, tumor, tumor-infiltrating
Référence
J Immunother Cancer. 2020 Nov;8(2):