The dysregulated innate immune response in severe COVID-19 pneumonia that could drive poorer outcome.
Fiche publication
Date publication
décembre 2020
Journal
Journal of translational medicine
Auteurs
Membres identifiés du Cancéropôle Est :
Pr BINQUET Christine, Mr MONIER Serge
Tous les auteurs :
Blot M, Bour JB, Quenot JP, Bourredjem A, Nguyen M, Guy J, Monier S, Georges M, Large A, Dargent A, Guilhem A, Mouries-Martin S, Barben J, Bouhemad B, Charles PE, Chavanet P, Binquet C, Piroth L,
Lien Pubmed
Résumé
Although immune modulation is a promising therapeutic avenue in coronavirus disease 2019 (COVID-19), the most relevant targets remain to be found. COVID-19 has peculiar characteristics and outcomes, suggesting a unique immunopathogenesis.
Mots clés
Acute respiratory distress syndrome, COVID-19, CXCL10, GM-CSF, Immune response, Mechanical ventilation, Pneumonia
Référence
J Transl Med. 2020 Dec 3;18(1):457