Astrocytoma: A Hormone-Sensitive Tumor?
Fiche publication
Date publication
novembre 2020
Journal
International journal of molecular sciences
Auteurs
Membres identifiés du Cancéropôle Est :
Dr DUBOIS-POT-SCHNEIDER Hélène, Dr DUMOND Hélène, Dr RECH Fabien
Tous les auteurs :
Hirtz A, Rech F, Dubois-Pot-Schneider H, Dumond H
Lien Pubmed
Résumé
Astrocytomas and, in particular, their most severe form, glioblastoma, are the most aggressive primary brain tumors and those with the poorest vital prognosis. Standard treatment only slightly improves patient survival. Therefore, new therapies are needed. Very few risk factors have been clearly identified but many epidemiological studies have reported a higher incidence in men than women with a sex ratio of 1:4. Based on these observations, it has been proposed that the neurosteroids and especially the estrogens found in higher concentrations in women's brains could, in part, explain this difference. Estrogens can bind to nuclear or membrane receptors and potentially stimulate many different interconnected signaling pathways. The study of these receptors is even more complex since many isoforms are produced from each estrogen receptor encoding gene through alternative promoter usage or splicing, with each of them potentially having a specific role in the cell. The purpose of this review is to discuss recent data supporting the involvement of steroids during gliomagenesis and to focus on the potential neuroprotective role as well as the mechanisms of action of estrogens in gliomas.
Mots clés
astrocytoma, estrogens, gender, glioblastoma, pregnancy, receptor isoforms, signaling, steroids
Référence
Int J Mol Sci. 2020 Nov 30;21(23):