Sensing and signalling viral infection in drosophila.
Fiche publication
Date publication
décembre 2020
Journal
Developmental and comparative immunology
Auteurs
Membres identifiés du Cancéropôle Est :
Pr IMLER Jean-Luc
Tous les auteurs :
Schneider J, Imler JL
Lien Pubmed
Résumé
The fruitfly Drosophila melanogaster is a valuable model to unravel mechanisms of innate immunity, in particular in the context of viral infections. RNA interference, and more specifically the small interfering RNA pathway, is a major component of antiviral immunity in drosophila. In addition, the contribution of inducible transcriptional responses to the control of viruses in drosophila and other invertebrates is increasingly recognized. In particular, the recent discovery of a STING-IKKβ-Relish signalling cassette in drosophila has confirmed that NF-κB transcription factors play an important role in the control of viral infections, in addition to bacterial and fungal infections. Here, we review recent developments in the field, which begin to shed light on the mechanisms involved in sensing of viral infections and in signalling leading to production of antiviral effectors.
Mots clés
Antiviral factors, Innate immunity, NF-κB, RNA interference, STING, Virus
Référence
Dev Comp Immunol. 2020 Dec 23;117:103985