Delivery of siRNA by tailored cell-penetrating urea-based foldamers.
Fiche publication
Date publication
janvier 2021
Journal
Chemical communications (Cambridge, England)
Auteurs
Membres identifiés du Cancéropôle Est :
Dr KICHLER Antoine
Tous les auteurs :
Bornerie M, Brion A, Guichard G, Kichler A, Douat C
Lien Pubmed
Résumé
Cell-penetrating foldamers (CPFs) have recently shown promise as efficient and safe nucleic acid delivery systems. However, the application of CPFs to siRNA transport remains scarce. Here, we report helical CPFs tailored with specific end-groups (pyridylthio- or n-octyl-ureas) as effective molecular systems in combination with helper lipids to intracellularly deliver biologically-relevant siRNA.
Référence
Chem Commun (Camb). 2021 Jan 13;: