Population pharmacokinetic and pharmacodynamic modeling of capecitabine and its metabolites in breast cancer patients.
Fiche publication
Date publication
janvier 2021
Journal
Cancer chemotherapy and pharmacology
Auteurs
Membres identifiés du Cancéropôle Est :
Pr PIVOT Xavier, Dr ROYER Bernard, Pr SCHMITT Antonin
Tous les auteurs :
Lunar N, Etienne-Grimaldi MC, Macaire P, Thomas F, Dalenc F, Ferrero JM, Pivot X, Milano G, Royer B, Schmitt A
Lien Pubmed
Résumé
The present study was performed to examine relationships between systemic exposure of capecitabine metabolites (5-FU, 5'-DFCR and 5'-DFUR) and toxicity or clinical response in patients with metastatic breast cancer.
Mots clés
Breast cancer, Capecitabine, Modelling, PD, PK, Toxicity
Référence
Cancer Chemother Pharmacol. 2021 Jan 2;: