Increased levels of circulating microparticles are associated with increased procoagulant activity in patients with cutaneous malignant melanoma.
Fiche publication
Date publication
janvier 2014
Auteurs
Membres identifiés du Cancéropôle Est :
Pr AUBIN François, Pr GARNACHE-OTTOU Francine, Pr HUMBERT Philippe, Mr LIHOREAU Thomas
Tous les auteurs :
Laresche C, Pelletier F, Garnache-Ottou F, Lihoreau T, Biichle S, Mourey G, Saas P, Humbert P, Seilles E, Aubin F
Lien Pubmed
Résumé
Microparticles (MPs) are known to be increased in various malignancies and are involved in tumor invasion, angiogenesis, coagulation, and metastasis. We investigated the plasma levels of annexin-V MPs (AV(+)MPs), platelet-derived MPs (PMPs), and endothelial-derived MPs (EMPs) in patients with melanoma (n=129) and in healthy controls (n=49). A functional coagulation test STA Procoag-PPL measuring the clotting time was performed on samples containing MPs to evaluate their procoagulant potential. The plasma levels of PMPs, EMPs, and AV(+)MPs were significantly higher, and the clotting time-PPL was significantly lower in melanoma patients than in healthy controls. The plasma levels of PMPs, EMPs, and AV(+)MPs were higher in stage IV than in the other stages of melanoma, but with no significant difference. In addition, we observed an inverse correlation between PMPs, AV(+)MPs, and clotting times. Our data suggest that MPs are involved in the progression of melanoma and may be associated to melanoma-associated thrombogenesis.
Référence
J Invest Dermatol. 2014 Jan;134(1):176-82