A NGS-based Blood Test for the Diagnosis of Invasive HPV-associated Carcinomas with Extensive Viral Genomic Characterization.
Fiche publication
Date publication
juin 2021
Journal
Clinical cancer research : an official journal of the American Association for Cancer Research
Auteurs
Membres identifiés du Cancéropôle Est :
Pr DOLIVET Gilles, Pr HARLE Alexandre, Dr LEROUX Agnès, Pr MARCHAL Frédéric, Pr MERLIN Jean-Louis, Pr PEIFFERT Didier, Dr LEUFFLEN Léa
Tous les auteurs :
Sastre-Garau X, Diop M, Martin F, Dolivet G, Marchal F, Charra-Brunaud C, Peiffert D, Leufflen L, Dembele B, Demange J, Tosti P, Thomas J, Leroux A, Merlin JL, Diop-Ndiaye H, Costa JM, Salleron J, Harle A
Lien Pubmed
Résumé
Use of circulating tumor DNA for diagnosis is limited regarding the low number of target molecules in early stage tumors. HPV-associated carcinomas represent a privileged model using circulating viral DNA (ctHPV DNA) as a tumor marker. However, the plurality of HPV genotypes represents a challenge. The NGS-based CaptHPV approach is able to characterize any HPV DNA sequence. To assess the ability of this method to establish the diagnosis of HPV-associated cancer via a blood sample, we analyzed ctHPV DNA in HPV-positive or HPV-negative carcinomas.
Référence
Clin Cancer Res. 2021 Jun 9;: