Early 18F-FDG PET Flare-up Phenomenon After CAR T-Cell Therapy in Lymphoma.
Fiche publication
Date publication
août 2021
Journal
Clinical nuclear medicine
Auteurs
Membres identifiés du Cancéropôle Est :
Pr VERGER Antoine
Tous les auteurs :
Boursier C, Perrin M, Bordonne M, Campidelli A, Verger A
Lien Pubmed
Résumé
18F-FDG PET/CT imaging series were acquired on a 64-year-old woman with refractory diffuse large B lymphoma to monitor chimeric antigen receptor (CAR) T-cell therapy. Because of a clinical deterioration, 18F-FDG PET/CT performed 8 days after CAR T-cell therapy suggested an early flare-up phenomenon with new lymph node involvement, lymph node progression while a decrease in metabolic tumor volume. The 18F-FDG PET/CT 1 month after CAR T-cell therapy confirmed this hypothesis. Pseudoprogression in solid tumors treated by immunotherapy has generally been reported later after treatment.
Référence
Clin Nucl Med. 2021 Aug 16;: