Electron-Beam-Induced Grafting of Chitosan onto HDPE/ATZ Composites for Biomedical Applications.
Fiche publication
Date publication
novembre 2021
Journal
Polymers
Auteurs
Membres identifiés du Cancéropôle Est :
Pr COQUERET Xavier
Tous les auteurs :
Faga MG, Duraccio D, Di Maro M, Kowandy C, Malucelli G, Mussano FD, Genova T, Coqueret X
Lien Pubmed
Résumé
The surface functionalisation of high-density polyethylene (HDPE) and HDPE/alumina-toughened zirconia (ATZ) surfaces with chitosan via electron-beam (EB) irradiation technique was exploited for preparing materials suitable for biomedical purposes. ATR-FTIR analysis and wettability measurements were employed for monitoring the surface changes after both irradiation and chitosan grafting reaction. Interestingly, the presence of ATZ loadings beyond 2 wt% influenced both the EB irradiation process and the chitosan functionalisation reaction, decreasing the oxidation of the surface and the chitosan grafting. The EB irradiation induced an increase in Young's modulus and a decrease in the elongation at the break of all analysed systems, whereas the tensile strength was not affected in a relevant way. Biological assays indicated that electrostatic interactions between the negative charges of the surface of cell membranes and the -NH sites on chitosan chains promoted cell adhesion, while some oxidised species produced during the irradiation process are thought to cause a detrimental effect on the cell viability.
Mots clés
alumina-toughened zirconia (ATZ), cell adhesion, chitosan, electron-beam irradiation, high-density polyethylene (HDPE), mechanical properties, nano-roughness, radiation-induced grafting, viability, wettability
Référence
Polymers (Basel). 2021 Nov 20;13(22):