Central metabolism as a potential origin of sex differences in morphine antinociception but not in the induction of antinociceptive tolerance in mice.
Fiche publication
Date publication
janvier 2022
Journal
British journal of pharmacology
Auteurs
Membres identifiés du Cancéropôle Est :
Dr GOUMON Yannick
Tous les auteurs :
Gabel F, Hovhannisyan V, Andry V, Goumon Y
Lien Pubmed
Résumé
In rodents, morphine antinociception is influenced by sex. However, conflicting results have been reported regarding the interaction between sex and morphine antinociceptive tolerance. Morphine is metabolised in the liver and brain into morphine-3-glucuronide (M3G). Sex differences in morphine metabolism and differential metabolic adaptations during tolerance development might contribute to behavioural discrepancies. This article investigates the differences in peripheral and central morphine metabolism after acute and chronic morphine treatment in male and female mice.
Mots clés
M3G, Morphine, UDP-glucuronosyltransferase, antinociception, antinociceptive tolerance, metabolism, sex differences
Référence
Br J Pharmacol. 2022 Jan 5;: