Targeting coagulation to unlock antitumor immunity?

Fiche publication


Date publication

janvier 2022

Journal

Oncoimmunology

Auteurs

Membres identifiés du Cancéropôle Est :
Pr GHIRINGHELLI François


Tous les auteurs :
Galmiche A, Saidak Z, Ghiringhelli F

Résumé

Besides a number of physical consequences (reduced blood supply, stabilization of circulating tumor microemboli, shielding from the attack of immune cells), the coagulation cascade may specifically regulate antitumor immunity. We recently applied systems biology and genomics to explore the regulation of the tumor immune microenvironment by coagulation.

Mots clés

Coagulome, antigen presentation, antitumor immunity, genomics, tissue factor, tumor microenvironment

Référence

Oncoimmunology. 2022 ;11(1):2045696