Lipophilic phthalocyanines for their potential interest in photodynamic therapy: synthesis and photo-physical properties.
Fiche publication
Date publication
novembre 2013
Auteurs
Membres identifiés du Cancéropôle Est :
Dr FROCHOT Céline, Dr VANDERESSE Régis
Tous les auteurs :
Moussaron A, Arnoux P, Vanderesse R, Sibille E, Chaimbault P, Frochot C
Lien Pubmed
Résumé
Several phthalocyanines with different peripheral substituents were prepared and characterized by MALDI-TOF, H-1 NMR, UV-vis, fluorescence, and singlet oxygen quantum yields and retention time in HPLC normal phase. Zinc was used as a central metal ion to increase the photodynamic therapy efficiency. Phthalonitrile or 4-nitro phthalonitriles were used as starting materials. The influence of lipophilicity on the photophysical and photochemical properties was evaluated. (C) 2013 Elsevier Ltd. All rights reserved.
Référence
Tetrahedron. 2013 Nov 25;69(47):10116-22.