NLRP6 negatively regulates type 2 immune responses in mice.
Fiche publication
Date publication
mai 2022
Journal
Allergy
Auteurs
Membres identifiés du Cancéropôle Est :
Dr VEGRAN Frédérique
Tous les auteurs :
Chenuet P, Marquant Q, Fauconnier L, Youness A, Mellier M, Marchiol T, Rouxel N, Messaoud-Nacer Y, Maillet I, Ledru A, Quesniaux VFJ, Ryffel B, Horsnell W, Végran F, Apetoh L, Togbe D
Lien Pubmed
Résumé
Inflammasomes are large protein complexes that assemble in the cytosol in response to danger such as tissue damage or infection. Following activation, inflammasomes trigger cell death and the release of biologically active forms of pro-inflammatory cytokines interleukin (IL)-1β and IL-18. NOD-like receptor family pyrin domain containing 6 (NLRP6) inflammasome is required for IL-18 secretion by intestinal epithelial cells, macrophages, and T cells, contributing to homeostasis and self-defense against pathogenic microbes. However, the involvement of NLRP6 in type 2 lung inflammation remains elusive.
Mots clés
Nippostrongylus brasiliensis , CD4+ T cells, GATA3, IL-18, ILC2, NLRP6, Th17, Th2, allergic asthma, birch pollen, inflammasome
Référence
Allergy. 2022 05 25;: