Microfluidics for High Pressure: Integration on GaAs Acoustic Biosensors with a Leakage-Free PDMS Based on Bonding Technology.
Fiche publication
Date publication
mai 2022
Journal
Micromachines
Auteurs
Membres identifiés du Cancéropôle Est :
Dr LEBLOIS Thérèse, Dr ELIE-CAILLE Céline
Tous les auteurs :
Hammami S, Oseev A, Bargiel S, Zeggari R, Elie-Caille C, Leblois T
Lien Pubmed
Résumé
Microfluidics integration of acoustic biosensors is an actively developing field. Despite significant progress in "passive" microfluidic technology, integration with microacoustic devices is still in its research state. The major challenge is bonding polymers with monocrystalline piezoelectrics to seal microfluidic biosensors. In this contribution, we specifically address the challenge of microfluidics integration on gallium arsenide (GaAs) acoustic biosensors. We have developed a robust plasma-assisted bonding technology, allowing strong connections between PDMS microfluidic chip and GaAs/SiO at low temperatures (70 °C). Mechanical and fluidic performances of fabricated device were studied. The bonding surfaces were characterized by water contact angle measurement and ATR-FTIR, AFM, and SEM analysis. The bonding strength was characterized using a tensile machine and pressure/leakage tests. The study showed that the sealed chips were able to achieve a limit of high bonding strength of 2.01 MPa. The adhesion of PDMS to GaAs was significantly improved by use of SiO intermediate layer, permitting the bonded chip to withstand at least 8.5 bar of burst pressure. The developed bonding approach can be a valuable solution for microfluidics integration in several types of MEMS devices.
Mots clés
PDMS- SiO2/GaAs bonding, acoustic biosensor, bonding technology, leakage test, microfluidics, microsystems
Référence
Micromachines (Basel). 2022 05 11;13(5):