Possible mediators of metabolic endotoxemia in women with obesity and women with obesity-diabetes in The Gambia.
Fiche publication
Date publication
août 2022
Journal
International journal of obesity (2005)
Auteurs
Membres identifiés du Cancéropôle Est :
Dr LAGROST Laurent
Tous les auteurs :
Jobe M, Agbla SC, Todorcevic M, Darboe B, Danso E, de Barros JP, Lagrost L, Karpe F, Prentice AM
Lien Pubmed
Résumé
Translocation of bacterial debris from the gut causes metabolic endotoxemia (ME) that results in insulin resistance, and may be on the causal pathway to obesity-related type 2 diabetes. To guide interventions against ME we tested two hypothesised mechanisms for lipopolysaccharide (LPS) ingress: a leaky gut and chylomicron-associated transfer following a high-fat meal.
Référence
Int J Obes (Lond). 2022 08 6;: