High field magnetic resonance imaging of rodents in cardiovascular research.
Fiche publication
Date publication
juillet 2016
Journal
Basic research in cardiology
Auteurs
Membres identifiés du Cancéropôle Est :
Dr PO Chrystelle
Tous les auteurs :
Vanhoutte L, Gerber BL, Gallez B, Po C, Magat J, Balligand JL, Feron O, Moniotte S
Lien Pubmed
Résumé
Transgenic and gene knockout rodent models are primordial to study pathophysiological processes in cardiovascular research. Over time, cardiac MRI has become a gold standard for in vivo evaluation of such models. Technical advances have led to the development of magnets with increasingly high field strength, allowing specific investigation of cardiac anatomy, global and regional function, viability, perfusion or vascular parameters. The aim of this report is to provide a review of the various sequences and techniques available to image mice on 7-11.7 T magnets and relevant to the clinical setting in humans. Specific technical aspects due to the rise of the magnetic field are also discussed.
Mots clés
Cardiovascular diseases, High field, MRI, Mouse
Référence
Basic Res Cardiol. 2016 07;111(4):46