High EGFR protein expression and exon 9 PIK3CA mutations are independent prognostic factors in triple negative breast cancers.
Fiche publication
Date publication
décembre 2015
Journal
BMC cancer
Auteurs
Membres identifiés du Cancéropôle Est :
Pr BIBEAU Frédéric
Tous les auteurs :
Jacot W, Mollevi C, Fina F, Lopez-Crapez E, Martin PM, Colombo PE, Bibeau F, Romieu G, Lamy PJ
Lien Pubmed
Résumé
Triple negative breast cancers (TNBC) are a more aggressive subset of breast cancer. A better understanding of its biology could allow the rational development of targeted therapies.
Mots clés
Adult, Aged, Aged, 80 and over, Class I Phosphatidylinositol 3-Kinases, ErbB Receptors, genetics, Exons, Female, Gene Amplification, Gene Expression Regulation, Neoplastic, Humans, Middle Aged, Mutation, PTEN Phosphohydrolase, genetics, Phosphatidylinositol 3-Kinases, genetics, Prognosis, Triple Negative Breast Neoplasms, genetics
Référence
BMC Cancer. 2015 Dec 18;15:986