Tear analysis as a tool to detect oligoclonal bands in radiologically isolated syndrome.
Fiche publication
Date publication
avril 2015
Journal
Revue neurologique
Auteurs
Membres identifiés du Cancéropôle Est :
Pr DE SEZE Jérôme
Tous les auteurs :
Lebrun C, Forzy G, Collongues N, Cohen M, de Seze J, Hautecoeur P,
Lien Pubmed
Résumé
Although radiologically isolated syndrome (RIS) is a newly defined entity, incidental findings of T2 hypersignals on brain MRI can lead to misdiagnosis or useless investigations. The detection of oligoclonal bands (OCBs) in cerebrospinal fluid (CSF) is a major indicator that helps in diagnosis of subclinical inflammatory disease of the central nervous system, but lumbar puncture still remains an invasive option.
Mots clés
Adult, Brain, pathology, Female, Humans, Isoelectric Focusing, Magnetic Resonance Imaging, Male, Middle Aged, Multiple Sclerosis, cerebrospinal fluid, Oligoclonal Bands, analysis, Prospective Studies, Spinal Puncture, Tears, chemistry, Young Adult
Référence
Rev. Neurol. (Paris). 2015 Apr;171(4):390-3