The Lauren classification highlights the role of epithelial-to-mesenchymal transition in gastric carcinogenesis: an immunohistochemistry study of the STAT3 and adhesion molecules expression.
Fiche publication
Date publication
mars 2015
Journal
Journal of gastrointestinal and liver diseases : JGLD
Auteurs
Membres identifiés du Cancéropôle Est :
Pr BIBEAU Frédéric
Tous les auteurs :
Susman S, Barnoud R, Bibeau F, Borrini F, Pocard M, Tomuleasa C, Sabourin JC
Lien Pubmed
Résumé
Despite some recent advances, gastric cancer remains an important cause of death at world level. This indicates an absence of therapeutic options, stemming from the limited understanding of the molecular mechanisms involved in carcinogenesis. Nearly fifty years ago Lauren classified gastric cancers, according to the morphological aspect, as intestinal or diffuse. The phenotype of the cells indicates the presence of different molecular mechanisms, which can be approached in the light of recent data and identified with the help of current techniques. The best described are the germline/somatic mutations or the hypermethylations of the E-cadherin 1 CDH1 gene promotor.
Mots clés
Adenocarcinoma, chemistry, Adult, Aged, Aged, 80 and over, Antigens, CD, Biomarkers, Tumor, analysis, Cadherins, analysis, Cell Adhesion Molecules, analysis, Epithelial-Mesenchymal Transition, Europe, Female, Humans, Immunohistochemistry, Male, Middle Aged, Phosphorylation, Prognosis, STAT3 Transcription Factor, analysis, Stomach Neoplasms, chemistry, Tissue Array Analysis, alpha Catenin, analysis, beta Catenin, analysis
Référence
J Gastrointestin Liver Dis. 2015 03;24(1):77-83