Red Light-Responsive Upconverting Nanoparticles for Quantitative and Controlled Release of a Coumarin-Based Prodrug.
Fiche publication
Date publication
octobre 2022
Journal
Advanced healthcare materials
Auteurs
Membres identifiés du Cancéropôle Est :
Dr FRISCH Benoit, Dr HEURTAULT Béatrice, Dr KICHLER Antoine, Dr SPECHT Alexandre
Tous les auteurs :
Brion A, Chaud J, Léonard J, Bolze F, Chassaing S, Frisch B, Heurtault B, Kichler A, Specht A
Lien Pubmed
Résumé
Photolytic reactions allow the optical control of the liberation of biological effectors by photolabile protecting groups. The development of versatile technologies enabling the use of deep-red or NIR light excitation still represents a challenging issue, in particular for light-induced drug release (eg; light induced prodrug activation). Here, we present light-sensitive biocompatible lipid nanocapsules able to liberate an antitumoral drug through photolysis. We demonstrate that original photon upconverting nanoparticles (LNC-UCs) chemically conjugated to a coumarin-based photocleavable linker can quantitatively and efficiently release a drug by upconversion luminescence-assisted photolysis using a deep-red excitation wavelength. In addition, we were also able to demonstrate that such nanoparticles are stable in the dark, without any drug leakage in the absence of light. These findings open new avenues to specifically liberate diverse drugs using deep-red or NIR excitations for future therapeutic applications in nanomedicine.) This article is protected by copyright. All rights reserved.
Mots clés
(Photon upconversion, Drug delivery, Nanoparticle, Photopharmacology), Uncaging
Référence
Adv Healthc Mater. 2022 10 12;:e2201474