Characterization of long non-coding RNA transcriptome in clear-cell renal cell carcinoma by next-generation deep sequencing.
Fiche publication
Date publication
janvier 2015
Journal
Molecular oncology
Auteurs
Membres identifiés du Cancéropôle Est :
Pr MALOUF Gabriel
Tous les auteurs :
Malouf GG, Zhang J, Yuan Y, Compérat E, Rouprêt M, Cussenot O, Chen Y, Thompson EJ, Tannir NM, Weinstein JN, Valero V, Khayat D, Spano JP, Su X
Lien Pubmed
Résumé
Long non-coding RNA (lncRNA) have proven to play key roles in cell physiology from nuclear organization and epigenetic remodeling to post-transcriptional regulation. Last decade, gene expression based-classifications have been developed in clear-cell renal cell carcinoma (ccRCC) to identify distinct subtypes of disease and predict patient's outcome. However, there are no current lncRNA comprehensive characterizations in ccRCC.
Mots clés
Adult, Aged, Aged, 80 and over, Carcinoma, Renal Cell, genetics, Databases, Nucleic Acid, Female, Gene Expression Regulation, Neoplastic, High-Throughput Nucleotide Sequencing, Humans, Kidney Neoplasms, genetics, Male, Middle Aged, Mutation, RNA, Long Noncoding, biosynthesis, RNA, Neoplasm, biosynthesis, Survival Rate
Référence
Mol Oncol. 2015 Jan;9(1):32-43